Fluorescent microscopy of sagittal sections from A2a-FlpO x RCE:FRT mouse: d1CreS1

Abstract

This dataset is part of a whole-brain imaging experiment describing the expression of Cre or FlpO recombinase in various regions of the brain from various newly-generated knock-in lines (D1-Cre, A2a-Cre, D1-FlpO, A2a-FlpO, DAT-FlpO). Knock-in recombinse lines were crosses to fluorescent reporter lines (e.g., Ai9) and then animals were perfused and imaged using fluorescent microscopy. Coronal and/or sagittal sections are present for each line to visualize brain-wide expression of the recombinase activity.

Contributors

• Albarran, Eddy ORCID Columbia University DataCollector
• Fushiki, Akira ORCID Allen Institute DataCollector
• Nelson, Anders ORCID New York University DataCollector
• Chaimowitz, Corryn ORCID New York University DataCollector
• Nikoobakht, Laudan ORCID Columbia University DataCollector
• Peterka, Darcy ORCID Columbia University ProjectLeader
• Costa, Rui M. ORCID Allen Institute ProjectLeader

Funding

• Aligning Science Across Parkinson's ASAP-020551 Distributed circuit dysfunction underlying motor and sleep deficits in a progressive mouse model of Parkinson’s disease

Data